RNA-directed remodeling of the HIV-1 protein Rev orchestrates assembly of the Rev–Rev response element complex

RNA-directed remodeling of the HIV-1 protein Rev orchestrates assembly of the Rev–Rev response element complex

The HIV-1 protein Rev controls a critical step in viral replication by mediating the nuclear export of unspliced and singly-spliced viral mRNAs. Multiple Rev subunits assemble on the Rev Response Element (RRE), a structured region present in these RNAs, and direct their export through the Crm1 pathw...

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Bibliographic Details
Main Authors: Bhargavi Jayaraman, David C Crosby, Christina Homer, Isabel Ribeiro, David Mavor, Alan D Frankel
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-12-01
Series:eLife
Subjects:
HIV
protein-RNA structure
nuclear export
Online Access:https://elifesciences.org/articles/04120

Internet

https://elifesciences.org/articles/04120

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