RNA-directed remodeling of the HIV-1 protein Rev orchestrates assembly of the Rev–Rev response element complex
The HIV-1 protein Rev controls a critical step in viral replication by mediating the nuclear export of unspliced and singly-spliced viral mRNAs. Multiple Rev subunits assemble on the Rev Response Element (RRE), a structured region present in these RNAs, and direct their export through the Crm1 pathw...
Main Authors: | Bhargavi Jayaraman, David C Crosby, Christina Homer, Isabel Ribeiro, David Mavor, Alan D Frankel |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2014-12-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/04120 |
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