Toxic properties of microsome-associated alpha-synuclein species in mouse primary neurons

Toxic properties of microsome-associated alpha-synuclein species in mouse primary neurons

α-synuclein (αS) is a small protein that self-aggregates into α-helical oligomer species and subsequently into larger insoluble amyloid fibrils that accumulate in intraneuronal inclusions during the development of Parkinson's disease. Toxicity of αS oligomers and fibrils has been long debated a...

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Bibliographic Details
Main Authors: Emanuela Colla, Giulia Panattoni, Alessio Ricci, Caterina Rizzi, Lucia Rota, Nicola Carucci, Verdiana Valvano, Francesco Gobbo, Simona Capsoni, Michael K. Lee, Antonino Cattaneo
Format: Article
Language:English
Published: Elsevier 2018-03-01
Series:Neurobiology of Disease
Subjects:
α-Synuclein
Microsomes
Endoplasmic reticulum
Oligomers
Aggregates
Neurodegeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996117302826

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http://www.sciencedirect.com/science/article/pii/S0969996117302826

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