Protective Effect of Protocatechuic Acid on TNBS-Induced Colitis in Mice Is Associated with Modulation of the SphK/S1P Signaling Pathway

Protective Effect of Protocatechuic Acid on TNBS-Induced Colitis in Mice Is Associated with Modulation of the SphK/S1P Signaling Pathway

(1) Background: The present study aimed to investigate whether beneficial effects of protocatechuic acid (PCA) are associated with inhibition of the SphK/S1P axis and related signaling pathways in a 2,4,6-trinitrobenzenesulfonic acid (TNBS) model of inflammatory bowel disease; (2) Methods: Colitis w...

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Bibliographic Details
Main Authors: Irene Crespo, Beatriz San-Miguel, José Luis Mauriz, Juan José Ortiz de Urbina, Mar Almar, María Jesús Tuñón, Javier González-Gallego
Format: Article
Language:English
Published: MDPI AG 2017-03-01
Series:Nutrients
Subjects:
protocatechuic acid
colitis
inflammation
sphingolipids
SphK/S1P signaling
Online Access:http://www.mdpi.com/2072-6643/9/3/288

Internet

http://www.mdpi.com/2072-6643/9/3/288

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