Distinct effects of ubiquitin overexpression on NMJ structure and motor performance in mice expressing catalytically inactive USP14

Distinct effects of ubiquitin overexpression on NMJ structure and motor performance in mice expressing catalytically inactive USP14

Ubiquitin-specific protease 14 (USP14) is a major deubiquitinating enzyme and a key determinant of neuromuscular junction (NMJ) structure and function. We have previously reported dramatic ubiquitin depletion in the nervous systems of the USP14-deficient ataxia (axJ) mice and demonstrated that trans...

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Bibliographic Details
Main Authors: Jada H Vaden, Jennifer Ashley Watson, Alan David Howard, Ping-Chung eChen, Julie Ann Wilson, Scott Michael Wilson
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-04-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Neuromuscular Junction
Ubiquitin
proteasomes
USP14
pJNK
motor neuron and deubiquitinating enzyme
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnmol.2015.00011/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnmol.2015.00011/full

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