Vildagliptin Attenuates Myocardial Dysfunction and Restores Autophagy via miR-21/SPRY1/ERK in Diabetic Mice Heart

Vildagliptin Attenuates Myocardial Dysfunction and Restores Autophagy via miR-21/SPRY1/ERK in Diabetic Mice Heart

Aim: Vildagliptin (vild) improves diastolic dysfunction and is associated with a lower relative risk of major adverse cardiovascular events in younger patients. The present study aimed to evaluate whether vild prevents the development of diabetic cardiomyopathy in type 2 diabetic mice and identify i...

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Bibliographic Details
Main Authors: Xiaochen Li, Cheng Meng, Fei Han, Juhong Yang, Jingyu Wang, Yanjuan Zhu, Xiao Cui, Minxia Zuo, Jie Xu, Baocheng Chang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Pharmacology
Subjects:
vildagliptin
diabetic cardiomyopathy
microRNA-21
autophagy
SPRY1
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.634365/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.634365/full

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