Expression of a recombinant bacterial l-asparaginase in human cells

Expression of a recombinant bacterial l-asparaginase in human cells

Abstract Objective l-Asparaginase (ASNase) is an enzyme used in the treatment of acute lymphoblastic leukemia (ALL). As the therapeutic ASNases has bacterial origin, severe side effects are associated with its use, among them hypersensitivity and inactivation of the enzyme. In this context, the obje...

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Main Authors: Raquel Caminha Dantas, Ludmilla Freire Caetano, Ariany Lima Sousa Torres, Matheus Soares Alves, Emanuelly Thays Muniz Figueiredo Silva, Louhanna Pinheiro Rodrigues Teixeira, Daniel Câmara Teixeira, Renato de Azevedo Moreira, Marcela Helena Gambim Fonseca, Saul Gaudêncio Neto, Leonardo Tondello Martins, Gilvan Pessoa Furtado, Kaio Cesar Simiano Tavares
Format: Article
Language:English
Published: BMC 2019-12-01
Series:BMC Research Notes
Subjects:
l-Asparaginase
Acute lymphoblastic leukemia
Glycosylation
Hypersensitivity
Online Access:https://doi.org/10.1186/s13104-019-4836-5

Internet

https://doi.org/10.1186/s13104-019-4836-5

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