Pathophysiological Relevance of Renal Medullary Conditions on the Behaviour of Red Cells From Patients With Sickle Cell Anaemia

Pathophysiological Relevance of Renal Medullary Conditions on the Behaviour of Red Cells From Patients With Sickle Cell Anaemia

Red cells from patients with sickle cell anaemia (SCA) contain the abnormal haemoglobin HbS. Under hypoxic conditions, HbS polymerises and causes red cell sickling, a rise in intracellular Ca2+ and exposure of phosphatidylserine (PS). These changes make sickle cells sticky and liable to lodge in the...

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Bibliographic Details
Main Authors: David C.-Y. Lu, Rasiqh Wadud, Anke Hannemann, David C. Rees, John N. Brewin, John Stanley Gibson
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Physiology
Subjects:
HbS polymerisation
sickling
phosphatidylserine
renal medulla
hypoxia
pH
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.653545/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2021.653545/full

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