PRSS1 mutation: a possible pathomechanism of pancreatic carcinogenesis and pancreatic cancer

PRSS1 mutation: a possible pathomechanism of pancreatic carcinogenesis and pancreatic cancer

Abstract Background Previous studies revealed somatic mutations of the cationic trypsinogen gene (PRSS1) in patients with chronic pancreatitis and pancreatic cancer. However, whether PRSS1 mutations trigger pancreatic cancer and/or promote malignant proliferation and metastasis in pancreatic cancer...

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Bibliographic Details
Main Authors: Qicai Liu, Ling Guo, Sheng Zhang, Jingwen Wang, Xinhua Lin, Feng Gao
Format: Article
Language:English
Published: BMC 2019-09-01
Series:Molecular Medicine
Subjects:
Pancreatic cancer
PRSS1 mutation
JAK1-STAT5
Transgenic mouse model
Online Access:http://link.springer.com/article/10.1186/s10020-019-0111-4

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