Characterization and oncolytic virus targeting of FAP-expressing tumor-associated pericytes in glioblastoma

Characterization and oncolytic virus targeting of FAP-expressing tumor-associated pericytes in glioblastoma

Abstract Cancer-associated fibroblasts (CAFs) are activated fibroblasts constituting the major stromal components in many types of cancer. CAFs contribute to hallmarks of cancer such as proliferation, invasion and immunosuppressive tumor microenvironment, and are associated with poor prognosis of pa...

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Bibliographic Details
Main Authors: Ming Li, Guoping Li, Juri Kiyokawa, Zain Tirmizi, Leland G. Richardson, Jianfang Ning, Saumya Das, Robert L. Martuza, Anat Stemmer-Rachamimov, Samuel D. Rabkin, Hiroaki Wakimoto
Format: Article
Language:English
Published: BMC 2020-12-01
Series:Acta Neuropathologica Communications
Subjects:
Glioblastoma
Tumor-associated fibroblasts
Pericytes
Oncolytic virus
FAP
Online Access:https://doi.org/10.1186/s40478-020-01096-0

Internet

https://doi.org/10.1186/s40478-020-01096-0

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