MicroRNA-9 downregulates the ANO1 chloride channel and contributes to cystic fibrosis lung pathology
Downregulation of the anoctamin 1 calcium channel in airway epithelial cells contributes to pathology in cystic fibrosis. Here the authors show that microRNA-9 targets anoctamin 1 and that inhibiting this interaction improves mucus dynamics in mouse models.
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2017-09-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-017-00813-z |