Directional divergence of Ep300 duplicates in teleosts and its implications

Directional divergence of Ep300 duplicates in teleosts and its implications

Abstract Background EP300 is a conserved protein in vertebrates, which serves as a key mediator of cellular homeostasis. Mutations and dysregulation of EP300 give rise to severe human developmental disorders and malignancy. Danio rerio is a promising model organism to study EP300 related diseases an...

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Bibliographic Details
Main Authors: Xianzong Wang, Junli Yan
Format: Article
Language:English
Published: BMC 2020-10-01
Series:BMC Evolutionary Biology
Subjects:
EP300
Lysine acetyltransferase
Teleost
Whole genome duplication
Divergent evolution
Positive selection
Online Access:http://link.springer.com/article/10.1186/s12862-020-01712-6

Internet

http://link.springer.com/article/10.1186/s12862-020-01712-6

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