CAR/FoxP3-engineered T regulatory cells target the CNS and suppress EAE upon intranasal delivery

CAR/FoxP3-engineered T regulatory cells target the CNS and suppress EAE upon intranasal delivery

<p>Abstract</p> <p>Background</p> <p>Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS). In the murine experimental autoimmune encephalomyelitis (EAE) model of MS, T regulatory (Treg) cell therapy has proved to be beneficial, but genera...

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Bibliographic Details
Main Authors: Fransson Moa, Piras Elena, Burman Joachim, Nilsson Berith, Essand Magnus, Lu BinFeng, Harris Robert A, Magnusson Peetra U, Brittebo Eva, Loskog Angelica SI
Format: Article
Language:English
Published: BMC 2012-05-01
Series:Journal of Neuroinflammation
Subjects:
MS
redirected cells
T regulatory cells
EAE
FoxP3
Myelin oligodendrocyte glycoprotein (MOG)
Online Access:http://www.jneuroinflammation.com/content/9/1/112

Internet

http://www.jneuroinflammation.com/content/9/1/112

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