VEGF‐B‐induced vascular growth leads to metabolic reprogramming and ischemia resistance in the heart

VEGF‐B‐induced vascular growth leads to metabolic reprogramming and ischemia resistance in the heart

Abstract Angiogenic growth factors have recently been linked to tissue metabolism. We have used genetic gain‐ and loss‐of function models to elucidate the effects and mechanisms of action of vascular endothelial growth factor‐B (VEGF‐B) in the heart. A cardiomyocyte‐specific VEGF‐B transgene induced...

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Bibliographic Details
Main Authors: Riikka Kivelä, Maija Bry, Marius R Robciuc, Markus Räsänen, Miia Taavitsainen, Johanna MU Silvola, Antti Saraste, Juha J Hulmi, Andrey Anisimov, Mikko I Mäyränpää, Jan H Lindeman, Lauri Eklund, Sanna Hellberg, Ruslan Hlushchuk, Zhen W Zhuang, Michael Simons, Valentin Djonov, Juhani Knuuti, Eero Mervaala, Kari Alitalo
Format: Article
Language:English
Published: Wiley 2014-03-01
Series:EMBO Molecular Medicine
Subjects:
angiogenesis
endothelial cell
ischemia
metabolism
VEGF‐B
Online Access:https://doi.org/10.1002/emmm.201303147

Internet

https://doi.org/10.1002/emmm.201303147

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