Identification of novel genes involved in apoptosis of HIV-infected macrophages using unbiased genome-wide screening

Identification of novel genes involved in apoptosis of HIV-infected macrophages using unbiased genome-wide screening

Abstract Background Macrophages, besides resting latently infected CD4+ T cells, constitute the predominant stable, major non-T cell HIV reservoirs. Therefore, it is essential to eliminate both latently infected CD4+ T cells and tissue macrophages to completely eradicate HIV in patients. Until now,...

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Bibliographic Details
Main Authors: Simon X. M. Dong, Frederick S. Vizeacoumar, Kalpana K. Bhanumathy, Nezeka Alli, Cristina Gonzalez-Lopez, Niranjala Gajanayaka, Ramon Caballero, Hamza Ali, Andrew Freywald, Edana Cassol, Jonathan B. Angel, Franco J. Vizeacoumar, Ashok Kumar
Format: Article
Language:English
Published: BMC 2021-07-01
Series:BMC Infectious Diseases
Subjects:
AIDS
Apoptosis
HIV reservoir
Genome-wide screening
Selective killing
Macrophages
Online Access:https://doi.org/10.1186/s12879-021-06346-7

Internet

https://doi.org/10.1186/s12879-021-06346-7

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