The Role of Combined Penetration Enhancers in Nasal Microspheres on In Vivo Drug Bioavailability

The Role of Combined Penetration Enhancers in Nasal Microspheres on In Vivo Drug Bioavailability

Microspheres based on both methyl-β-cyclodextrins and chitosan were prepared by spray-drying as nasal formulations of a model polar drug to analyze, firstly, how the composition of the carrier affects drug permeation across synthetic membranes and, secondly, how it induces systemic or brain...

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Bibliographic Details
Main Authors: Giovanna Rassu, Luca Ferraro, Barbara Pavan, Paolo Giunchedi, Elisabetta Gavini, Alessandro Dalpiaz
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:Pharmaceutics
Subjects:
combined microsphere
chitosan
cyclodextrin
nasal delivery
nose to brain transport
penetration enhancer
nasal formulation
in vivo studies
Online Access:https://www.mdpi.com/1999-4923/10/4/206

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https://www.mdpi.com/1999-4923/10/4/206

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