An additional NF-κB site allows HIV-1 subtype C to evade restriction by nuclear PYHIN proteins

An additional NF-κB site allows HIV-1 subtype C to evade restriction by nuclear PYHIN proteins

Summary: Subtype C is the most prevalent clade of human immunodeficiency virus type 1 (HIV-1) worldwide. The reasons for this are poorly understood. Here, we demonstrate that a characteristic additional third nuclear factor κB (NF-κB) binding site in the long terminal repeat (LTR) promoter allows su...

Full description

Bibliographic Details
Main Authors: Matteo Bosso, Christina M. Stürzel, Dorota Kmiec, Smitha Srinivasachar Badarinarayan, Elisabeth Braun, Jumpei Ito, Kei Sato, Beatrice H. Hahn, Konstantin M.J. Sparrer, Daniel Sauter, Frank Kirchhoff
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Cell Reports
Subjects:
HIV-1 subtypes
innate immunity
PYHIN proteins
Gamma Interferon Inducible Protein 16
specificity protein 1
nuclear factor-κB
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721011840

Internet

http://www.sciencedirect.com/science/article/pii/S2211124721011840

Similar Items