Direct conversion of porcine primary fibroblasts into hepatocyte-like cells

Abstract The pig is an important model organism for biomedical research, mainly due to its extensive genetic, physiological and anatomical similarities with humans. Until date, direct conversion of somatic cells into hepatocyte-like cells (iHeps) has only been achieved in rodents and human cells. He...

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Bibliographic Details
Main Authors: Mariane Fráguas-Eggenschwiler, Reto Eggenschwiler, Jenny-Helena Söllner, Leon Cortnumme, Florian W. R. Vondran, Tobias Cantz, Michael Ott, Heiner Niemann
Format: Article
Language:English
Published: Nature Publishing Group 2021-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-88727-1