Hypomethylating Agent Azacitidine Is Effective in Treating Brain Metastasis Triple-Negative Breast Cancer Through Regulation of DNA Methylation of Keratin 18 Gene

Hypomethylating Agent Azacitidine Is Effective in Treating Brain Metastasis Triple-Negative Breast Cancer Through Regulation of DNA Methylation of Keratin 18 Gene

Breast cancer patients presenting with symptomatic brain metastases have poor prognosis, and current chemotherapeutic agents are largely ineffective. In this study, we evaluated the hypomethylating agent azacitidine (AZA) for its potential as a novel therapeutic in preclinical models of brain metast...

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Bibliographic Details
Main Authors: Christopher Butler, Samuel Sprowls, Gabor Szalai, Tasneem Arsiwala, Pushkar Saralkar, Benjamin Straight, Shea Hatcher, Evan Tyree, Michael Yost, William J. Kohler, Benjamin Wolff, Emily Putnam, Paul Lockman, Tuoen Liu
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Translational Oncology
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523320301145

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http://www.sciencedirect.com/science/article/pii/S1936523320301145

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