Anti-Inflammatory Effects of Tanshinone IIA on Atherosclerostic Vessels of Ovariectomized ApoE-/- Mice are Mediated by Estrogen Receptor Activation and Through the ERK Signaling Pathway

Anti-Inflammatory Effects of Tanshinone IIA on Atherosclerostic Vessels of Ovariectomized ApoE-/- Mice are Mediated by Estrogen Receptor Activation and Through the ERK Signaling Pathway

Aims: Estrogen plays a protective role in atherosclerosis. Our preliminary work demonstrated that the active conformation of Tanshinone IIA(TanIIA) is similar to the 17ß-estradiol and it can bind to the estrogen receptor. Here, we hypothesized that Tanshinone IIA might have anti-inflammatory and ant...

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Bibliographic Details
Main Authors: Xin Liu, Chun-Yu Guo, Xiao-Juan Ma, Cai-Feng Wu, Ying Zhang, Ming-Yue Sun, Yu-Ting Pan, Hui-Jun Yin
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-03-01
Series:Cellular Physiology and Biochemistry
Subjects:
17β-estradiol
Atherosclerosis
Anti-inflammation
ApoE-/- mice
ICI182780
ERK1/2
Online Access:http://www.karger.com/Article/FullText/373986

Internet

http://www.karger.com/Article/FullText/373986

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