Treatment of cardiac arrhythmias in a mouse model of Rett syndrome with Na+-channel-blocking antiepileptic drugs

Treatment of cardiac arrhythmias in a mouse model of Rett syndrome with Na+-channel-blocking antiepileptic drugs

One quarter of deaths associated with Rett syndrome (RTT), an X-linked neurodevelopmental disorder, are sudden and unexpected. RTT is associated with prolonged QTc interval (LQT), and LQT-associated cardiac arrhythmias are a potential cause of unexpected death. The standard of care for LQT in RTT is...

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Bibliographic Details
Main Authors: José A. Herrera, Christopher S. Ward, Meagan R. Pitcher, Alan K. Percy, Steven Skinner, Walter E. Kaufmann, Daniel G. Glaze, Xander H. T. Wehrens, Jeffrey L. Neul
Format: Article
Language:English
Published: The Company of Biologists 2015-04-01
Series:Disease Models & Mechanisms
Subjects:
Long QT
Rett syndrome
Propranolol
Phenytoin
Arrhythmia
MECP2
Online Access:http://dmm.biologists.org/content/8/4/363

Internet

http://dmm.biologists.org/content/8/4/363

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