The functional O-mannose glycan on α-dystroglycan contains a phospho-ribitol primed for matriglycan addition

The functional O-mannose glycan on α-dystroglycan contains a phospho-ribitol primed for matriglycan addition

Multiple glycosyltransferases are essential for the proper modification of alpha-dystroglycan, as mutations in the encoding genes cause congenital/limb-girdle muscular dystrophies. Here we elucidate further the structure of an O-mannose-initiated glycan on alpha-dystroglycan that is required to gene...

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Bibliographic Details
Main Authors: Jeremy L Praissman, Tobias Willer, M Osman Sheikh, Ants Toi, David Chitayat, Yung-Yao Lin, Hane Lee, Stephanie H Stalnaker, Shuo Wang, Pradeep Kumar Prabhakar, Stanley F Nelson, Derek L Stemple, Steven A Moore, Kelley W Moremen, Kevin P Campbell, Lance Wells
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-04-01
Series:eLife
Subjects:
congenital muscular dystrophy
O-mannosylation
glycosylation
alpha-dystroglycan
ribitol
mass spectrometry
Online Access:https://elifesciences.org/articles/14473

Internet

https://elifesciences.org/articles/14473

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