Tau-Cofactor Complexes as Building Blocks of Tau Fibrils

The aggregation of the human tau protein into neurofibrillary tangles is directly diagnostic of many neurodegenerative conditions termed tauopathies. The species, factors and events that are responsible for the initiation and propagation of tau aggregation are not clearly established, even in a simp...

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Bibliographic Details
Main Authors: Yann Fichou, Zachary R. Oberholtzer, Hoang Ngo, Chi-Yuan Cheng, Timothy J. Keller, Neil A. Eschmann, Songi Han
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Neuroscience
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.01339/full