Sequencing Shorter cfDNA Fragments Decreases the False Negative Rate of Non-invasive Prenatal Testing

Sequencing Shorter cfDNA Fragments Decreases the False Negative Rate of Non-invasive Prenatal Testing

Circulating fetal cell-free DNA (cfDNA) is generally shorter than maternal cfDNA. Size selection of shorter cfDNA in total cfDNA could significantly increase the fetal fraction, but there are few reports of using this method to decrease the false negative rate for NIPT. In this study, nine false neg...

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Bibliographic Details
Main Authors: Ying Xue, Guodong Zhao, Longwei Qiao, Jiafeng Lu, Bin Yu, Ting Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Genetics
Subjects:
NIPT
false negative
shorter cfDNA fragments
size selection
twin pregnancies
confined placental mosaicism
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2020.00280/full

Internet

https://www.frontiersin.org/article/10.3389/fgene.2020.00280/full

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