Decreased Soluble Human Leukocyte Antigen E Levels in Patients After Allogeneic Hematopoietic Stem Cell Transplantation Are Associated With Severe Acute and Extended Chronic Graft-versus-Host Disease and Inferior Overall Survival

Decreased Soluble Human Leukocyte Antigen E Levels in Patients After Allogeneic Hematopoietic Stem Cell Transplantation Are Associated With Severe Acute and Extended Chronic Graft-versus-Host Disease and Inferior Overall Survival

HLA-E is a member of the non-classical HLA molecules and by interaction with activating or inhibitory receptors of NK and T cells, HLA-E can lead to immune activation or suppression context-dependently. Recently, the non-classical HLA molecules gain more attention in the setting of allogeneic hemato...

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Bibliographic Details
Main Authors: Lambros Kordelas, Esther Schwich, Monika Lindemann, Falko M. Heinemann, Ulrike Buttkereit, Peter A. Horn, Dietrich W. Beelen, Vera Rebmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Immunology
Subjects:
allogeneic hematopoietic stem cell transplantation
graft-versus-host disease
GvHD biomarker
HLA
HLA-E
HLA-G
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.03027/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.03027/full

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