Angiotensin II-induced upregulation of SGLT1 and 2 contributes to human microparticle‐stimulated endothelial senescence and dysfunction: protective effect of gliflozins

Angiotensin II-induced upregulation of SGLT1 and 2 contributes to human microparticle‐stimulated endothelial senescence and dysfunction: protective effect of gliflozins

Abstract Background Sodium-glucose cotransporter 2 (SGLT2) inhibitors reduced cardiovascular risk in type 2 diabetes patients independently of glycemic control. Although angiotensin II (Ang II) and blood-derived microparticles are major mediators of cardiovascular disease, their impact on SGLT1 and...

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Bibliographic Details
Main Authors: Sin-Hee Park, Eugenia Belcastro, Hira Hasan, Kensuke Matsushita, Benjamin Marchandot, Malak Abbas, Florence Toti, Cyril Auger, Laurence Jesel, Patrick Ohlmann, Olivier Morel, Valérie B. Schini-Kerth
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Cardiovascular Diabetology
Subjects:
Endothelial senescence and dysfunction
Angiotensin II
Circulating microparticles
SGLT1
SGLT2
Empagliflozin
Online Access:https://doi.org/10.1186/s12933-021-01252-3

Internet

https://doi.org/10.1186/s12933-021-01252-3

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