The effects of flutamide on the neonatal rat hypothalamic–pituitary–adrenal and gonadal axes in response to hypoxia

Abstract Hypoxia is common with preterm birth and may lead to long‐term effects on the adult hypothalamic–pituitary–adrenal (HPA) axis that are sexually dimorphic due to neonatal androgens. Although the adult rat adrenal does not express appreciable CYP17 activity, the neonatal rat adrenal may synth...

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Bibliographic Details
Main Authors: Santiago Rolon, Christine Huynh, Maya Guenther, Minhal Gardezi, Jonathan Phillips, Ashley L. Gehrand, Hershel Raff
Format: Article
Language:English
Published: Wiley 2019-12-01
Series:Physiological Reports
Subjects:
Online Access:https://doi.org/10.14814/phy2.14318