Identification and engineering of 32 membered antifungal macrolactone notonesomycins

Identification and engineering of 32 membered antifungal macrolactone notonesomycins

Abstract Notonesomycin A is a 32-membered bioactive glycosylated macrolactone known to be produced by Streptomyces aminophilus subsp. notonesogenes 647-AV1 and S. aminophilus DSM 40186. In a high throughput antifungal screening campaign, we identified an alternative notonesomycin A producing strain,...

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Bibliographic Details
Main Authors: Falicia Goh, Mingzi M. Zhang, Tian Ru Lim, Kia Ngee Low, Choy Eng Nge, Elena Heng, Wan Lin Yeo, Fernanda L. Sirota, Sharon Crasta, Zann Tan, Veronica Ng, Chung Yan Leong, Huibin Zhang, Alexander Lezhava, Swaine L. Chen, Shawn S. Hoon, Frank Eisenhaber, Birgit Eisenhaber, Yoganathan Kanagasundaram, Fong T. Wong, Siew Bee Ng
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Microbial Cell Factories
Subjects:
Natural product
Polyketide
Biosynthetic gene cluster
CRISPR–Cas9
Sulfation
Streptomyces antibiotic regulatory protein
Online Access:http://link.springer.com/article/10.1186/s12934-020-01328-x

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http://link.springer.com/article/10.1186/s12934-020-01328-x

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