The Blood-Brain Barrier Breakdown During Acute Phase of the Pilocarpine Model of Epilepsy Is Dynamic and Time-Dependent

The Blood-Brain Barrier Breakdown During Acute Phase of the Pilocarpine Model of Epilepsy Is Dynamic and Time-Dependent

The maintenance of blood-brain barrier (BBB) integrity is essential for providing a suitable environment for nervous tissue function. BBB disruption is involved in many central nervous system diseases, including epilepsy. Evidence demonstrates that BBB breakdown may induce epileptic seizures, and co...

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Bibliographic Details
Main Authors: Natália Ferreira Mendes, Aline Priscila Pansani, Elis Regina Ferreira Carmanhães, Poliana Tange, Juliana Vieira Meireles, Mayara Ochikubo, Jair Ribeiro Chagas, Alexandre Valotta da Silva, Glaucia Monteiro de Castro, Luciana Le Sueur-Maluf
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Neurology
Subjects:
epilepsy
blood-brain barrier
pilocarpine
status epilepticus
Evans blue
sodium fluorescein
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2019.00382/full

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https://www.frontiersin.org/article/10.3389/fneur.2019.00382/full

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