Increased rates of cerebral protein synthesis in Shank3 knockout mice: Implications for a link between synaptic protein deficit and dysregulated protein synthesis in autism spectrum disorder/intellectual disability

Increased rates of cerebral protein synthesis in Shank3 knockout mice: Implications for a link between synaptic protein deficit and dysregulated protein synthesis in autism spectrum disorder/intellectual disability

SHANK3 is a postsynaptic scaffolding protein that plays a critical role in synaptic development and brain function. Mutations in SHANK3 are implicated in Phelan-McDermid syndrome (PMS), a neurodevelopmental disorder characterized by autistic-like behavior, delayed speech, hypotonia, and intellectual...

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Bibliographic Details
Main Authors: Anita Torossian, Rachel Michelle Saré, Inna Loutaev, Carolyn Beebe Smith
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Neurobiology of Disease
Subjects:
Shank3
Phelan McDermid syndrome
mRNA translation: protein synthesis rates
Autism spectrum disorders
Intellectual disability
MAPK/ERK
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996120304885

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http://www.sciencedirect.com/science/article/pii/S0969996120304885

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