MiR-221/222 target the DNA methyltransferase MGMT in glioma cells.

MiR-221/222 target the DNA methyltransferase MGMT in glioma cells.

Glioblastoma multiforme (GBM) is one of the most deadly types of cancer. To date, the best clinical approach for treatment is based on administration of temozolomide (TMZ) in combination with radiotherapy. Much evidence suggests that the intracellular level of the alkylating enzyme O(6)-methylguanin...

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Bibliographic Details
Main Authors: Cristina Quintavalle, Davide Mangani, Giuseppina Roscigno, Giulia Romano, Angel Diaz-Lagares, Margherita Iaboni, Elvira Donnarumma, Danilo Fiore, Pasqualino De Marinis, Ylermi Soini, Manel Esteller, Gerolama Condorelli
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3798259?pdf=render

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http://europepmc.org/articles/PMC3798259?pdf=render

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