Matrix Gla protein maintains normal and malignant hematopoietic progenitor cells by interacting with bone morphogenetic protein-4

Matrix Gla protein maintains normal and malignant hematopoietic progenitor cells by interacting with bone morphogenetic protein-4

Matrix Gla protein (MGP), a modulator of the BMP-SMAD signals, inhibits arterial calcification in a Glu γ-carboxylation dependent manner but the role of MGP highly expressed in a subset of bone marrow (BM) mesenchymal stem/stromal cells is unknown. Here we provide evidence that MGP might be a niche...

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Bibliographic Details
Main Authors: Kana Kuronuma, Aya Yokoi, Tomoya Fukuoka, Muneaki Miyata, Akio Maekawa, Satowa Tanaka, Leo Matsubara, Chie Goto, Miki Matsuo, Hao-Wei Han, Mai Tsuruta, Haruka Murata, Hikari Okamoto, Natsumi Hasegawa, Shigetaka Asano, Mitsuhiro Ito
Format: Article
Language:English
Published: Elsevier 2020-04-01
Series:Heliyon
Subjects:
Biochemistry
Cancer research
Cell biology
Molecular biology
Physiology
Stem cells research
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844020305880

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http://www.sciencedirect.com/science/article/pii/S2405844020305880

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