Pentoxifylline Sensitizes Cisplatin-Resistant Human Cervical Cancer Cells to Cisplatin Treatment: Involvement of Mitochondrial and NF-Kappa B Pathways

Pentoxifylline Sensitizes Cisplatin-Resistant Human Cervical Cancer Cells to Cisplatin Treatment: Involvement of Mitochondrial and NF-Kappa B Pathways

BackgroundCervical cancer continues to be a major public health problem worldwide, and Cisplatin is used as first-line chemotherapy for this cancer; however, malignant cells exposed to CISplatin (CIS) become insensitive to the effects of this drug. PenToXifylline (PTX) is a xanthine that sensitizes...

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Bibliographic Details
Main Authors: Alejandro Bravo-Cuellar, Pablo Cesar Ortiz-Lazareno, Erick Sierra-Díaz, Fabiola Solorzano-Ibarra, Anibal Samael Méndez-Clemente, Adriana Aguilar-Lemarroy, Luis Felipe Jave-Suárez, Édgar Ruiz Velazco-Niño, Georgina Hernández-Flores
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Oncology
Subjects:
pentoxifylline
cervical cancer cells
chemoresistance
cisplatin
NF-KappaB
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.592706/full

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https://www.frontiersin.org/articles/10.3389/fonc.2020.592706/full

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