Oral Squamous Cell Carcinoma Contributes to Differentiation of Monocyte-Derived Tumor-Associated Macrophages via PAI-1 and IL-8 Production

Oral Squamous Cell Carcinoma Contributes to Differentiation of Monocyte-Derived Tumor-Associated Macrophages via PAI-1 and IL-8 Production

Tumor-associated macrophages (TAMs) promote cancer cell proliferation and metastasis, as well as anti-tumor immune suppression. Recent studies have shown that tumors enhance the recruitment and differentiation of TAMs, but the detailed mechanisms have not been clarified. We thus examined the influen...

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Bibliographic Details
Main Authors: Kazuki Kai, Masafumi Moriyama, A. S. M. Rafiul Haque, Taichi Hattori, Akira Chinju, Chen Hu, Keigo Kubota, Yuka Miyahara, Noriko Kakizoe-Ishiguro, Shintaro Kawano, Seiji Nakamura
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
tumor-associated macrophage
oral squamous cell carcinoma
CD206
plasminogen activator inhibitor–1
interleukin-8
Online Access:https://www.mdpi.com/1422-0067/22/17/9475

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https://www.mdpi.com/1422-0067/22/17/9475

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