Enhancing durability of CIS43 monoclonal antibody by Fc mutation or AAV delivery for malaria prevention

Enhancing durability of CIS43 monoclonal antibody by Fc mutation or AAV delivery for malaria prevention

CIS43 is a potent neutralizing human mAb that targets a highly conserved “junctional” epitope in the Plasmodium falciparum (Pf) circumsporozoite protein (PfCSP). Enhancing the durability of CIS43 in vivo will be important for clinical translation. Here, 2 approaches were used to improve the durabili...

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Bibliographic Details
Main Authors: Neville K. Kisalu, Lais D. Pereira, Keenan Ernste, Yevel Flores-Garcia, Azza H. Idris, Mangaiarkarasi Asokan, Marlon Dillon, Scott MacDonald, Wei Shi, Xuejun Chen, Amarendra Pegu, Arne Schön, Fidel Zavala, Alejandro B. Balazs, Joseph R. Francica, Robert A. Seder
Format: Article
Language:English
Published: American Society for Clinical investigation 2021-02-01
Series:JCI Insight
Subjects:
Infectious disease
Online Access:https://doi.org/10.1172/jci.insight.143958

Internet

https://doi.org/10.1172/jci.insight.143958

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