Treatment with MOG-DNA vaccines induces CD4<sup>+</sup>CD25<sup>+</sup>FoxP3<sup>+</sup> regulatory T cells and up-regulates genes with neuroprotective functions in experimental autoimmune encephalomyelitis

Treatment with MOG-DNA vaccines induces CD4<sup>+</sup>CD25<sup>+</sup>FoxP3<sup>+</sup> regulatory T cells and up-regulates genes with neuroprotective functions in experimental autoimmune encephalomyelitis

<p>Abstract</p> <p>Background</p> <p>DNA vaccines represent promising therapeutic strategies in autoimmune disorders such as multiple sclerosis (MS). However, the precise mechanisms by which DNA vaccines induce immune regulation remain largely unknown. Here, we aimed to...

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Bibliographic Details
Main Authors: Fissolo Nicolás, Costa Carme, Nurtdinov Ramil N, Bustamante Marta F, Llombart Victor, Mansilla María J, Espejo Carmen, Montalban Xavier, Comabella Manuel
Format: Article
Language:English
Published: BMC 2012-06-01
Series:Journal of Neuroinflammation
Subjects:
MS
EAE
DNA vaccines
Neuroprotection
Tolerance
Online Access:http://www.jneuroinflammation.com/content/9/1/139

Internet

http://www.jneuroinflammation.com/content/9/1/139

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