Compound Discovery and Structure-Activity Relationship Study of Neoantimycins Against Drug-Resistant Cancer Cells

Compound Discovery and Structure-Activity Relationship Study of Neoantimycins Against Drug-Resistant Cancer Cells

Four neoantimycins H-K (1–4) with C1-keto, including the new ones (1–2), were isolated from the culture of Streptomyces conglobatus RJ8. After enzymatically converting into their respective reduced type derivatives (5–8) in vitro, the absolute structures of 1–8 were established/reconfirmed by analyz...

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Bibliographic Details
Main Authors: Xiao Lin, Yongjun Zhou, Liyun Liu, Hongrui Zhu, Yeping Chen, Shuping Wang, Fan Sun, Ling Chai, Buming Liu, Shihai Xu, Hou-Wen Lin
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Chemistry
Subjects:
neoantimycins
streptomyces conglobatus
structural characterization
enzymatically conversion
absolute structure
drug-resistant cancer cell lines
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2019.00481/full

Internet

https://www.frontiersin.org/article/10.3389/fchem.2019.00481/full

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