Enhanced Phenotype Definition for Precision Isolation of Precursor Exhausted Tumor-Infiltrating CD8 T Cells

Enhanced Phenotype Definition for Precision Isolation of Precursor Exhausted Tumor-Infiltrating CD8 T Cells

In the context of adoptive T cell transfer (ACT) for cancer treatment, it is crucial to generate in vitro large amounts of tumor-specific CD8 T cells with high potential to persist in vivo. PD-1, Tim3, and CD39 have been proposed as markers of tumor-specific tumor-infiltrating CD8 T lymphocytes (CD8...

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Bibliographic Details
Main Authors: Amaia Martinez-Usatorre, Santiago J. Carmona, Céline Godfroid, Céline Yacoub Maroun, Sara Labiano, Pedro Romero
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Immunology
Subjects:
tumor-infiltrating CD8 T cells
precursor exhausted T cells
memory-like CD8 T cells
adoptive cell transfer
melanoma
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00340/full

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https://www.frontiersin.org/article/10.3389/fimmu.2020.00340/full

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