DEVELOPMENT AND VALIDATION OF METHODS OF QUANTITATIVE DETERMINATION OF THE NEW ANTIDIABETIC DRUG IN THE BLOOD PLASMA OF RATS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY WITH MASS SPECTROMETRIC DETECTION

We developed a method of quantification of the new antidiabetic drug 3-(1h-benzimidazole-2-yl)-1,2,2-trimethyl-cyclopentane-carbonic acid (c7070) in the blood plasma of rats by high-performance liquid chromatography with mass-spectrometric detection. The analytical range of the method was 0.02-3876....

Full description

Bibliographic Details
Main Authors: Andrey Buzov, Alexandr Kulikov, Tatyana Avtina, Mikhail Pokrovskii, Ol'ga Osipova
Format: Article
Language:English
Published: Pensoft Publishers 2016-03-01
Series:Research Results in Pharmacology
Subjects:
Online Access:https://rrpharmacology.pensoft.net/article/31041/download/pdf/