DEVELOPMENT AND VALIDATION OF METHODS OF QUANTITATIVE DETERMINATION OF THE NEW ANTIDIABETIC DRUG IN THE BLOOD PLASMA OF RATS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY WITH MASS SPECTROMETRIC DETECTION

DEVELOPMENT AND VALIDATION OF METHODS OF QUANTITATIVE DETERMINATION OF THE NEW ANTIDIABETIC DRUG IN THE BLOOD PLASMA OF RATS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY WITH MASS SPECTROMETRIC DETECTION

We developed a method of quantification of the new antidiabetic drug 3-(1h-benzimidazole-2-yl)-1,2,2-trimethyl-cyclopentane-carbonic acid (c7070) in the blood plasma of rats by high-performance liquid chromatography with mass-spectrometric detection. The analytical range of the method was 0.02-3876....

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Main Authors: Andrey Buzov, Alexandr Kulikov, Tatyana Avtina, Mikhail Pokrovskii, Ol'ga Osipova
Format: Article
Language:English
Published: Pensoft Publishers 2016-03-01
Series:Research Results in Pharmacology
Subjects:
antidiabetic agent
С7070
the blood plasma of rat
Online Access:https://rrpharmacology.pensoft.net/article/31041/download/pdf/
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spelling doaj-ec29302af6604d10ab8987a2284677a42021-05-21T15:15:41ZengPensoft PublishersResearch Results in Pharmacology2658-381X2016-03-0121525710.18413/2313-8971-2016-2-1-52-5731041DEVELOPMENT AND VALIDATION OF METHODS OF QUANTITATIVE DETERMINATION OF THE NEW ANTIDIABETIC DRUG IN THE BLOOD PLASMA OF RATS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY WITH MASS SPECTROMETRIC DETECTIONAndrey BuzovAlexandr KulikovTatyana AvtinaMikhail PokrovskiiOl'ga OsipovaWe developed a method of quantification of the new antidiabetic drug 3-(1h-benzimidazole-2-yl)-1,2,2-trimethyl-cyclopentane-carbonic acid (c7070) in the blood plasma of rats by high-performance liquid chromatography with mass-spectrometric detection. The analytical range of the method was 0.02-3876.0 μg in 1 ml of blood plasma. The research was partially supported by the grant of the President of the Russian Federation № MD-4711.2015.7 and МК-6135.2016.4.https://rrpharmacology.pensoft.net/article/31041/download/pdf/antidiabetic agentС7070the blood plasma of rat
collection DOAJ
language English
format Article
sources DOAJ
author Andrey Buzov
Alexandr Kulikov
Tatyana Avtina
Mikhail Pokrovskii
Ol'ga Osipova
spellingShingle Andrey Buzov
Alexandr Kulikov
Tatyana Avtina
Mikhail Pokrovskii
Ol'ga Osipova
DEVELOPMENT AND VALIDATION OF METHODS OF QUANTITATIVE DETERMINATION OF THE NEW ANTIDIABETIC DRUG IN THE BLOOD PLASMA OF RATS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY WITH MASS SPECTROMETRIC DETECTION
Research Results in Pharmacology
antidiabetic agent
С7070
the blood plasma of rat
author_facet Andrey Buzov
Alexandr Kulikov
Tatyana Avtina
Mikhail Pokrovskii
Ol'ga Osipova
author_sort Andrey Buzov
title DEVELOPMENT AND VALIDATION OF METHODS OF QUANTITATIVE DETERMINATION OF THE NEW ANTIDIABETIC DRUG IN THE BLOOD PLASMA OF RATS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY WITH MASS SPECTROMETRIC DETECTION
title_short DEVELOPMENT AND VALIDATION OF METHODS OF QUANTITATIVE DETERMINATION OF THE NEW ANTIDIABETIC DRUG IN THE BLOOD PLASMA OF RATS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY WITH MASS SPECTROMETRIC DETECTION
title_full DEVELOPMENT AND VALIDATION OF METHODS OF QUANTITATIVE DETERMINATION OF THE NEW ANTIDIABETIC DRUG IN THE BLOOD PLASMA OF RATS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY WITH MASS SPECTROMETRIC DETECTION
title_fullStr DEVELOPMENT AND VALIDATION OF METHODS OF QUANTITATIVE DETERMINATION OF THE NEW ANTIDIABETIC DRUG IN THE BLOOD PLASMA OF RATS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY WITH MASS SPECTROMETRIC DETECTION
title_full_unstemmed DEVELOPMENT AND VALIDATION OF METHODS OF QUANTITATIVE DETERMINATION OF THE NEW ANTIDIABETIC DRUG IN THE BLOOD PLASMA OF RATS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY WITH MASS SPECTROMETRIC DETECTION
title_sort development and validation of methods of quantitative determination of the new antidiabetic drug in the blood plasma of rats by high performance liquid chromatography with mass spectrometric detection
publisher Pensoft Publishers
series Research Results in Pharmacology
issn 2658-381X
publishDate 2016-03-01
description We developed a method of quantification of the new antidiabetic drug 3-(1h-benzimidazole-2-yl)-1,2,2-trimethyl-cyclopentane-carbonic acid (c7070) in the blood plasma of rats by high-performance liquid chromatography with mass-spectrometric detection. The analytical range of the method was 0.02-3876.0 μg in 1 ml of blood plasma. The research was partially supported by the grant of the President of the Russian Federation № MD-4711.2015.7 and МК-6135.2016.4.
topic antidiabetic agent
С7070
the blood plasma of rat
url https://rrpharmacology.pensoft.net/article/31041/download/pdf/
work_keys_str_mv AT andreybuzov developmentandvalidationofmethodsofquantitativedeterminationofthenewantidiabeticdruginthebloodplasmaofratsbyhighperformanceliquidchromatographywithmassspectrometricdetection
AT alexandrkulikov developmentandvalidationofmethodsofquantitativedeterminationofthenewantidiabeticdruginthebloodplasmaofratsbyhighperformanceliquidchromatographywithmassspectrometricdetection
AT tatyanaavtina developmentandvalidationofmethodsofquantitativedeterminationofthenewantidiabeticdruginthebloodplasmaofratsbyhighperformanceliquidchromatographywithmassspectrometricdetection
AT mikhailpokrovskii developmentandvalidationofmethodsofquantitativedeterminationofthenewantidiabeticdruginthebloodplasmaofratsbyhighperformanceliquidchromatographywithmassspectrometricdetection
AT olgaosipova developmentandvalidationofmethodsofquantitativedeterminationofthenewantidiabeticdruginthebloodplasmaofratsbyhighperformanceliquidchromatographywithmassspectrometricdetection
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