Discovery of Mycobacterium tuberculosis protein tyrosine phosphatase B (PtpB) inhibitors from natural products.

Discovery of Mycobacterium tuberculosis protein tyrosine phosphatase B (PtpB) inhibitors from natural products.

Protein tyrosine phosphatase B (PtpB) is one of the virulence factors secreted into the host cell by Mycobacterium tuberculosis. PtpB attenuates host immune defenses by interfering with signal transduction pathways in macrophages and, therefore, it is considered a promising target for the developmen...

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Bibliographic Details
Main Authors: Alessandra Mascarello, Mattia Mori, Louise Domeneghini Chiaradia-Delatorre, Angela Camila Orbem Menegatti, Franco Delle Monache, Franco Ferrari, Rosendo Augusto Yunes, Ricardo José Nunes, Hernán Terenzi, Bruno Botta, Maurizio Botta
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3796549?pdf=render

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http://europepmc.org/articles/PMC3796549?pdf=render

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