Differential in vitro activity of the DNA topoisomerase inhibitor idarubicin against Trypanosoma rangeli and Trypanosoma cruzi

Differential in vitro activity of the DNA topoisomerase inhibitor idarubicin against Trypanosoma rangeli and Trypanosoma cruzi

In this study the effect of eight DNA topoisomerase inhibitors on the growth Trypanosoma rangeli epimastigotes in cell culture was investigated. Among the eight compounds tested, idarubicin was the only compound that displayed promising trypanocidal activity with a half-maximal growth inhibition (GI...

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Bibliographic Details
Main Authors: Momodou Jobe, Charles Anwuzia-Iwegbu, Ama Banful, Emma Bosier, Mubeen Iqbal, Kelly Jones, Suzanne J Lecutier, Kasimir Lepper, Matt Redmond, Andrew Ross-Parker, Emily Ward, Paul Wernham, Eleanor M Whidden, Kevin M Tyler, Dietmar Steverding
Format: Article
Language:English
Published: Instituto Oswaldo Cruz, Ministério da Saúde 2012-11-01
Series:Memórias do Instituto Oswaldo Cruz.
Subjects:
Trypanosoma rangeli
Trypanosoma cruzi
Chagas disease
DNA topoisomerase inhibitors
drug screening
chemotherapy
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000700018&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000700018&lng=en&tlng=en

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