Expression of Class I Histone Deacetylases Indicates Poor Prognosis in Endometrioid Subtypes of Ovarian and Endometrial Carcinomas

Histone deacetylase (HDAC) inhibitors are an emerging class of targeted cancer therapeutics, and little is known about HDAC expression in gynecologic malignancies. Therefore, we tested the hypothesis whether high-level expression of class 1 HDACs (HDAC1, 2, and 3) is associated with clinically dist...

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Bibliographic Details
Main Authors: Wilko Weichert, Carsten Denkert, Aurelia Noske, Silvia Darb-Esfahani, Manfred Dietel, Steve E. Kalloger, David G. Huntsman, Martin Köbel
Format: Article
Language:English
Published: Elsevier 2008-09-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558608801406