EGFR-TKIs resistance via EGFR-independent signaling pathways

EGFR-TKIs resistance via EGFR-independent signaling pathways

Abstract Tyrosine kinase inhibitors (TKIs)-treatments bring significant benefit for patients harboring epidermal growth factor receptor (EGFR) mutations, especially for those with lung cancer. Unfortunately, the majority of these patients ultimately develop to the acquired resistance after a period...

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Bibliographic Details
Main Authors: Qian Liu, Shengnan Yu, Weiheng Zhao, Shuang Qin, Qian Chu, Kongming Wu
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Molecular Cancer
Subjects:
EGFR
TKIs
RTKs
ErbB
Drug resistance
Bypass signalings
Online Access:http://link.springer.com/article/10.1186/s12943-018-0793-1

Internet

http://link.springer.com/article/10.1186/s12943-018-0793-1

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