The membrane protein ANKH is crucial for bone mechanical performance by mediating cellular export of citrate and ATP.

The membrane protein ANKH is crucial for bone mechanical performance by mediating cellular export of citrate and ATP.

The membrane protein ANKH was known to prevent pathological mineralization of joints and was thought to export pyrophosphate (PPi) from cells. This did not explain, however, the presence of ANKH in tissues, such as brain, blood vessels and muscle. We now report that in cultured cells ANKH exports AT...

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Bibliographic Details
Main Authors: Flora Szeri, Stefan Lundkvist, Sylvia Donnelly, Udo F H Engelke, Kyu Rhee, Charlene J Williams, John P Sundberg, Ron A Wevers, Ryan E Tomlinson, Robert S Jansen, Koen van de Wetering
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-07-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1008884

Internet

https://doi.org/10.1371/journal.pgen.1008884

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