CENP-A overexpression promotes distinct fates in human cells, depending on p53 status

CENP-A overexpression promotes distinct fates in human cells, depending on p53 status

Jeffery et al. develop a system of inducible and reversible CENP-A overexpression, combined with a switch in p53 status in human cell lines. They find the tumor suppressor p53 as a key determinant of how CENP-A impacts cell state, cell identity and therapeutic response. This study suggests that CENP...

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Bibliographic Details
Main Authors: Daniel Jeffery, Alberto Gatto, Katrina Podsypanina, Charlène Renaud-Pageot, Rebeca Ponce Landete, Lorraine Bonneville, Marie Dumont, Daniele Fachinetti, Geneviève Almouzni
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-01941-5

Internet

https://doi.org/10.1038/s42003-021-01941-5

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