Mutant huntingtin induces iron overload via up-regulating IRP1 in Huntington’s disease

Mutant huntingtin induces iron overload via up-regulating IRP1 in Huntington’s disease

Abstract Background Iron accumulation in basal ganglia accompanies neuronal loss in Huntington’s disease (HD) patients and mouse disease models. Disruption of HD brain iron homeostasis occurs before the onset of clinical signs. Therefore, investigating the mechanism of iron accumulation is essential...

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Bibliographic Details
Main Authors: Li Niu, Cuifang Ye, Yun Sun, Ting Peng, Shiming Yang, Weixi Wang, He Li
Format: Article
Language:English
Published: BMC 2018-07-01
Series:Cell & Bioscience
Subjects:
Huntington’s disease
Iron
Iron response protein 1
Transferrin receptor
Transferrin
Ferritin
Online Access:http://link.springer.com/article/10.1186/s13578-018-0239-x

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http://link.springer.com/article/10.1186/s13578-018-0239-x

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