Combination of a Latency-Reversing Agent With a Smac Mimetic Minimizes Secondary HIV-1 Infection in vitro

Combination of a Latency-Reversing Agent With a Smac Mimetic Minimizes Secondary HIV-1 Infection in vitro

Latency-reversing agents (LRAs) are considered a potential tool to cure human immunodeficiency virus type 1 (HIV-1) infection, but when they are taken alone, virus production by reactivated cells and subsequent infection will occur. Hence, it is crucial to simultaneously take appropriate measures to...

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Bibliographic Details
Main Authors: Shin-ichiro Hattori, Kouki Matsuda, Kiyoto Tsuchiya, Hiroyuki Gatanaga, Shinichi Oka, Kazuhisa Yoshimura, Hiroaki Mitsuya, Kenji Maeda
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Microbiology
Subjects:
HIV
latency-reversing agent
Smac mimetic
birinapant
PKC activator
caspase-3
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.02022/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2018.02022/full

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