Epigenetic Deregulation of the Histone Methyltransferase KMT5B Contributes to Malignant Transformation in Glioblastoma

Epigenetic Deregulation of the Histone Methyltransferase KMT5B Contributes to Malignant Transformation in Glioblastoma

Glioblastoma multiforme (GBM) is the most common and aggressive type of brain tumor in adulthood. Epigenetic mechanisms are known to play a key role in GBM although the involvement of histone methyltransferase KMT5B and its mark H4K20me2 has remained largely unexplored. The present study shows that...

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Bibliographic Details
Main Authors: Virginia López, Juan Ramón Tejedor, Antonella Carella, María G. García, Pablo Santamarina-Ojeda, Raúl F. Pérez, Cristina Mangas, Rocío G. Urdinguio, Aitziber Aranburu, Daniel de la Nava, María D. Corte-Torres, Aurora Astudillo, Manuela Mollejo, Bárbara Meléndez, Agustín F. Fernández, Mario F. Fraga
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
epigenetics
glioblastoma
histone methyltransferase
histone posttranslational modification
tumor suppressor
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.671838/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.671838/full

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