MTHFR A1298C polymorphisms reduce the risk of congenital heart defects: a meta-analysis from 16 case-control studies

MTHFR A1298C polymorphisms reduce the risk of congenital heart defects: a meta-analysis from 16 case-control studies

Abstract Background Methylenetetrahydrofolate reductase (MTHFR) plays a crucial role in the hyperhomocysteinemia, which is a risk factor related to the occurrence of congenital heart defect (CHD). However, the association between MTHFR polymorphism and CHD has been inconclusive. Methods We conducted...

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Bibliographic Details
Main Authors: Di Yu, Zhulun Zhuang, Zhongyuan Wen, Xiaodong Zang, Xuming Mo
Format: Article
Language:English
Published: BMC 2017-12-01
Series:Italian Journal of Pediatrics
Subjects:
Methylenetetrahydrofolate reductase
Polymorphism
Congenital heart defects
Meta-analysis
Risk factor
Online Access:http://link.springer.com/article/10.1186/s13052-017-0425-1

Internet

http://link.springer.com/article/10.1186/s13052-017-0425-1

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